信號通路marker指標(biāo)分析
(molecular markers and signaling pathway)
技術(shù)概述
探討細(xì)胞信號通路和信號轉(zhuǎn)導(dǎo),關(guān)鍵基因研究。可以使用轉(zhuǎn)錄組、DGE、WB、qPCR、ELISA等技術(shù)進(jìn)行檢測。
常見信號通路:
Akt Signaling Pathway
The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a ‘pro-survival’ pathway.分析.png)
AMPK Signaling Pathway
AMPK signaling pathway plays an important role in the cellular response to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia. 分析02.png)
Apoptosis Signaling Pathway
Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell “suicide”. Apoptosis can be triggered by events both inside and outside of the cell.分析03.png)
Estrogen Signaling Pathway
Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.分析04.png)
Insulin Signaling Pathway
Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.分析05.png)
JAK-STAT Signaling Pathway
The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.分析06.png)
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division,
metabolism and survival.分析07.png)
mTOR Signaling Pathway
mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulatescell growth, proliferation and survival.分析08.png)
NF-κB Signaling Pathway
NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.分析09.png)
Notch Signaling Pathway
The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signaling can cause developmental defects and a range of adult pathologies.分析10.png)
p53 Signaling Pathway
p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage andhypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.分析11.png)
TGF-β Signaling Pathway
The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.分析12.png)
Toll-like Receptor Signaling Pathway
TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.分析13.png)
VEGF Signaling Pathway
VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.分析14.png)
Wnt Signaling Pathway
The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumorsand promote metastasis.分析15.png)
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